Population pharmacokinetic study of biapenem in critical patients
- Author:
Ya-Fang CHEN
1
Author Information
- Publication Type:Journal Article
- Keywords: Biapenem; Critical patient; Population pharmacokinetics
- From: Chinese Pharmaceutical Journal 2016;51(6):478-482
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To research population pharmacokinetics of biapenem in critical patients after repeated dosing. METHODS: Blood samples were collected according to the different time points after intravenous administration of 300 mg for many times in the group of critical patients. High-performance liquid chromatography (HPLC) was used to determine the drug concentration in plasma.And pharmacokinetic parameters was caculated. RESULTS: The main pharmacokinetic parameters for critical patients were as follows: ρmax was (6.66±2.93)mg·L-1, Tmax was (0.51±0.04) h, AUC0-∞ was (18.98±16.95) mg·h·L-1, T1/2 was (2.06±1.93) h, Cl was (20.9±17.4) L·h-1, Vd was (46.43±3.5) L. CONCLUSION: The pharmacokinetic parameters of biapenem in critical patients with a significant difference was found in healthy people. So need according to pharmacokinetic characteristics of patients to develop personalized anti-infection plan.
