Comparison of the properties of curcumin solid dispersions prepared by different technologies
- Author:
Nian-Qiu SHI
1
Author Information
- Publication Type:Journal Article
- Keywords: Curcumin; Optimal preparation technology; Property; Solid dispersion
- From: Chinese Pharmaceutical Journal 2016;51(10):821-826
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To prepare curcumin solid dispersions by different preparation technologies and compare their properties. METHODS: Curcumin/poloxamer 407 solid dispersions were prepared by freeze-drying, co-precipitation and microwave/quench cooling methods, respectively. Internal properties of obtained solid dispersion were analyzed by SEM, DSC, XRD and FT-IR. The improvement effect on the insolubility of curcumin by making it into solid dispersions by different technologies was characterized by dissolution and solubility experiments. RESULTS: Curcumin was dispersed in solid dispersions in micro-crystal form. Compared with other technologies, microwave/quench cooling method could significantly improve the solubility and dissolution of insoluble curcumin. CONCLUSION: The study provides reference for choice of applicable production technology for solid dispersions of insoluble Chinese traditional medicine curcumin.
