An exploring research about preparation technology and released effect of tamsulosion hydrochloride sustained-released capsules
- Author:
Hong-Lian DAI
1
Author Information
- Publication Type:Journal Article
- Keywords: Pharmaceutical technology; Release in vitro; Sustained-release capsule; Sustained-release pellets; Tamsulosin hydrochloride
- From: Chinese Pharmaceutical Journal 2016;51(18):1586-1591
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To study the preparation technology of tamsulosion hydrochloride sustained-release capsules and investigate the release degree in vitro. METHODS: The pellets containing tamsulosin hydrochloride were prepeared in the fluid-bed using bottom gush medicine. Then, it was coated with ethylcellulose aqueous dispersion (surelease), and in the following procedures, water-based acrylic resin enteric system (Acryl-EZE®) was used as coating material, hydroxypropylmethylcellulose E6 (HPMCE6) was considered as porous agent by fluid-bed. Based on the release degree in vitro, prescription influence factors were evaluated, as well as drug releases curve was compared, according to the single factor experiment. RESULTS: The preparation technology referred in our research was available to make tamsulosin hydrochloride sustained-release capsules, and drug release curve of self-made sustained-release capsules was similar to the commercial one. Additionally, the products reproducibility of intra-batch and inter-batch was excellent. CONCLUSION: The tamsulosin hydrochloride sustained-release capsules prepared in this study exhibited ideal sustained-release characteristics in vitro. The formulation is reasonable and feasible. It is suitable for industrial production.
