Mechanism research of apatinib-treated breast cancer based on network pharmacology
- Author:
Wan-Ting ZHU
1
Author Information
- Publication Type:Journal Article
- Keywords: Apatinib; Breast cancer; Molecular docking; Network pharmacology; Target predict
- From: Chinese Pharmaceutical Journal 2016;51(18):1569-1571
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To study the potential targets and action mechanism of apatinib-treated breast cancer. METHODS: Combination with bioinformatic analysis, PharmMapper reverse docking technology was used to predict potential targets of apatinib and docking was performed using Autodock 4. 0 to examine the interaction of aptinib wih predicted protein targets. RESULTS: Cell division protein kinase 2,GTPase HRas, NONE and cytochrome P450 2C9 were found to be the potential targets of apatinib-treated breast cancer. Stable hydrogen bonds were formed between apatinib and the four predicted targets, and the binding free energy was low. CONCLUSION: Apatinib maybe participate the functional regulation or biological action of cell division protein kinase 2, GTPase HRas, NONE and Cytochrome P4502C9 to treat breast cancer, which provides a theoretical basis and a clue for further exploration of the mechanism research of apatinib-treated breast cancer.
