A new cytotoxic triterpenoid from microtropis triflora merr. et freem
- Author:
Pei DING
1
Author Information
- Publication Type:Journal Article
- Keywords: 3, 25-epoxy-lα, 3α, 11α, 12, 23, 25-hexahydroxy-urs-12-en; Celastraceae; Chemical constituent; Microtropis triflora; Triterpene; Tumor cytotoxic acivity
- From: Chinese Pharmaceutical Journal 2016;51(18):1557-1561
- CountryChina
- Language:Chinese
- Abstract: To study the chemical constituents of Microtropis triflora Merr. et Freem. METHODS: The compounds were isolated and purified by various chromatographic technigues such as silica gel, Sephadex LH -20, and pre-HPLC. Their structures were identified on the basis of chemical properties and spectral analysis. RESULTS: Ten triterpenes were isolated and elucidated as 3, 25-epoxy-lα, 3α, 11α 12, 23, 25-hexahydroxy-urs-12-en(l), β-amyrin(2), β-amyrin palmitate(3), 3β-hydroxy-l1-oxo-olean-12-enyl-3-palmitate(4), lupeol(5), friedelin (6), 3-oxo-28-friedelanoic acid(7), oleanolic acid(8), salaspermic acid (9), and orthosphenic acid(10). CONCLUSION: Compound 1 is a new compound and has cytotoxic activity against Bcap37 and SMMC7721 cells with IC50 values of 27.86 and 11.38 μg· mL-1, respectively.
