Analysis of the polymorphs of carbamazepin tablets by laser confocal micro-Raman spectrometer and establishment of the identification test model
- Author:
Yun-Feng SHI
1
Author Information
- Publication Type:Journal Article
- Keywords: Carbamazepin tablet; Cluster analysis; Factorization method; Identificationtest model; Laser confocal micro-Raman spectra; Polymorphs analysi
- From: Chinese Pharmaceutical Journal 2016;51(19):1690-1694
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To analyze the polymorphs of carbamazepin tablets by laser confocal micro-Raman spectrometer and establish the identification test model. METHODS: Reference Raman spectra of the four crystal forms of carbamazepin were established; then the polymorphs of the carbamazepin tablets from different manufacturers were analyzed, and an identification test model was established to distinguish the unknown samples. RESULTS: According to the results of the cluster analysis, the four batches of carbamazepin tablets from domestic manufacturers belonged to crystal form III. A qualitative model was created by choosing the first derivative and vector normalization method to process the spectra, using the factorization method to calculate, and selecting the 200-500, 650-850, 1 000-1 100, 1 500-1 700 cm-1 regions to compare. This model was verified to have high sensitivity, specificity, precisicion, negative prediction ability, and detection efficiency. CONCLUSION: The laser confocal micro-Raman spectrometer canbe used to analyze the polymorphs of carbamazepin tablets and the qualitative identification is rapid and accurate.
