Using nonparametric test to analyze the relationship between hygroscopicity and water solubility of chemical drugs
- Author:
Jing XIONG
1
Author Information
- Publication Type:Journal Article
- Keywords: Chemical drug; Dynamic vapor sorption; Hygroscopicity; Kruskal-Wallis; Non-parametric test; Solubility; Wilcoxon
- From: Chinese Pharmaceutical Journal 2016;51(20):1786-1789
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To analyze the relationship between hygroscopicity and water solubility of chemical drugs by using nonparametric test. METHODS: Dynamic vapor sorption (DVS) analysis was adopted to determine the hygroscopicity of 515 chemical drugs, and solubility test method was adopted to determine the water solubility of these drugs. All samples were divided into four levels according to their water solubility, and the relationship between hygroscopicity and water solubility was investigated by using Kruskal-Wallis&Wilcoxon rank sum test. RESULTS: There were significant differences in the hygroscopicity of drugs with different levels of water solubility, and the hygroscopicity of level 4 was significantly higher than that of level 1. Hygroscopicity was positively correlated with water solubility. CONCLUSION The hygroscopicity of chemical drugs is interpreted in terms of a physical property in this study, and the results provide an experimental foundation for further studies on the mechanism of hygroscopicity.
