A preliminary study on the bone-targeting potential of a new type of bisphosphonate in rabbits
- Author:
Jun-Nan PAN
1
Author Information
- Publication Type:Journal Article
- Keywords: 99Tcm; Bisphosphonate; Bone Imaging; Bone-targeting; Osteoporosis; Selenium-containing bisphosphonate
- From: Chinese Pharmaceutical Journal 2016;51(20):1771-1775
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To study the bone-targeting potential and dynamic changing process in vivo of a new type of anti-osteoporosis bisphosphonate drug under research (SC). METHODS: The distribution in rabbits and bone-targeting of SC was observed by isotope tracer technique. 99Tcm-SC was injected into the rabbits, then the SPECT images were collected and analyzed in 12 h. RESULTS: The labeling rate of 99Tcm-SC could be maintained above 90% within 12 h, which proved the good stability of 99Tcm-SC in vitro. The rabbit bone imaging showed that the targeting of SC to bone was equivalent to MDP, a bone imaging agent. CONCLUSION: This study provides valuable data for the non-clinical and clinical studies of SC. SC has a good potential for being developed into a new generation of anti-osteoporosis drug.
