Effect of typical antidepressant drugs on the serum endogenous metabolites profile in rat
- Author:
Jian-Ye LIU
1
Author Information
- Publication Type:Journal Article
- Keywords: Chronic unpredictable mild stress; Metabolomics; Paroxetine; St.John'swort extract; Venlafaxine
- From: Chinese Pharmaceutical Journal 2016;51(23):2018-2024
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To explore the mechanism of venlafaxine, paroxetine and St. John's wort extract by comparing the changes of endogenous metabolites profile in rat serum. METHODS: These three drugs were employed to intervene in rats exposed to the chronic unpredictable mild stress (CUMS). Serum samples from all of rats were collected for a 1H-NMR metabolomics analysis to find the differences of metabolic profile. RESULTS: The resulting metabolic profiles demonstrated that these three antidepressants have an obvious difference effect on the endogenous metabolites in serum of the CUMS rats. It was also shown that the differential metabolites could be reversed in different degree. Six metabolites could be callback by venlafaxine while 4 metabolites by paroxetine and five metabolites by St. John's wort extract, in which lactate, choline, N-acetyl glycoprotein could be regulated to normal by all these three drugs. CONCLUSION: The different drugs have difference regulation on the type and level of the endogenous metabolites, but also have similarities, which can provide a reference for the better understanding of the mechanism of antidepressant drugs.
