Effect of solvent pH on properties and clinical use of four drugs in gynecology and obstetrics
- Author:
Bo-Ran DU
1
Author Information
- Publication Type:Journal Article
- Keywords: Gynecology and obstetrics; Intravenous injection; pH; Simulation; Solvent
- From: Chinese Pharmaceutical Journal 2016;51(24):2175-2194
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To investigate the effect of solvent pH on the physical/chemical properties and clinical use of four drugs commonly used in gynecology and obstetrics, including aminophylline, ambroxol, labetalol and ritodrine, through simulation and evidence-based evaluation to provide theoretical guidance and quantitative reference for clinical use. METHODS: By searching PubMed compound and Martindale: The Complete Drug Reference, the physical/chemical and clinical information of the four drugs were obtained. The logP, pKa, logD, and solubility were simulated using ACD/LAB 6.0 software. RESULTS: The solvent pH had effects on the logD and solubility of the four drugs to a certain degree in an exponential manner. The four drugs are compatible with dextrose injection or 0.9% sodium chloride injection, but special care needs to be taken in the clinical use. CONCLUSION: Solvent pH has influence on the dissolution balance of the four drugs. Simulation of the physical/chemical properties of drugs will provide theoretical guidance and reference for clinicians with more detailed information.
