Comprehensive evaluation of use of paclobutrazol in the cultivation of Ophiopogonis radix based on safety and efficacy
- Author:
Fa-Ming WU
1
Author Information
- Publication Type:Journal Article
- Keywords: Efficacy; Flavonoid; Ophiopogonis Radix; Paclobutrazol; Polysaccharide; Safety; Saponins
- From: Chinese Pharmaceutical Journal 2017;52(1):20-24
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To provide a theoretical basis for scientific and rational use of paclobutrazol in the production of Ophiopogonis Radix. METHODS: Different concentrations of paclobutrazol were applied to Ophiopogonis Radix plants, and medicinal samples were colleted. The efficacy of Ophiopogonis Radix were comprehensively analyzed from the appearance of the herb and the contents of three kinds of effective components: flavonoids, saponins, and polysaccharides. Residues of paclobutrazol were detected. The effect of paclobutrazol use on the safety of Ophiopogonis Radix was evaluated according to the acceptable daily intake (ADI) of paclobutrazol in the GB2763-2014 and the amount of usage of paclobutrazol required by Chinese Pharmacopoeia. RESULTS: Paclobutrazol had no significant effects on the Ophiopogonis Radix appearance; and the contents of polysaccharides and flavonoid were increased in varying degrees, and saponins content were decreased. The daily intake of paclobutrazol was far less than the ADI (0.1 mg·kg-1 × body weight) when calculated using the maximum residue of paclobutrazol at the usage of 3 kg·acres-1 and the maximum usage amount of Ophiopogonis Radix in Chinese Pharmacopoeia. CONCLUSION: Paclobutrazol can be used within limits according to the actual situation in Ophiopogonis Radix production.
