Clinical Availability of Topographic Auditory Event Related Potentials in Children with Attention Deficit Hyperactivity Disorder.
- Author:
Tae Shik LIM
1
;
Sang Ick HAN
;
Yang Whan JEON
;
Seung Kyu BANG
Author Information
1. Department of Neuropsychiatry, Our Lady of Mercy Hospital, The Catholic University of Korea, Inchon.
- Publication Type:Original Article
- Keywords:
Attention deficit hyperactivity disorder(ADHD);
Topographic auditory event related potential;
P300
- MeSH:
Attention Deficit Disorder with Hyperactivity*;
Biomarkers;
Child*;
Evoked Potentials*;
Female;
Humans;
Methylphenidate
- From:Journal of Korean Neuropsychiatric Association
2001;40(1):127-134
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: This study was carried out to investigate the clinical availability of topographic auditory event related potential P300 as a biological marker in children with attention deficit hyperactivity disorder(ADHD). METHODS: The subjects were composed of children with ADHD(n=22:16 boys, 6 girl s:mean age=89.8+/-17.1months) and normal controls(n=20:12 boys, 8 girls:mean age=90.6+/-16.8months). Topographic auditory event related potential was measured by "oddball paradigm", and the latencies and amplitudes of P300 of both groups were determined by Global Field Power Measurement. After 8 weeks treatment with methylphenidate, P300 of ADHD children were also measured. RESULTS: Both P300 latency and amplitude were not different between ADHD children after treatment and normal controls, but significantly different between ADHD children before treatment and normal controls, and between before and after treatment of ADHD children. CONCLUSIONS: The results implicate that the latency and amplitude of P300 may be considered as state markers of ADHD.
