Advances in research on application of magnesium aluminumsilicatein pharmaceutics
- Author:
Shi-Jie GU
1
Author Information
- Publication Type:Journal Article
- Keywords: Amorphous; Magnesium aluminum silicate; Pharmaceutical excipients
- From: Chinese Pharmaceutical Journal 2017;52(4):263-266
- CountryChina
- Language:Chinese
- Abstract: The research progress of the application of magnesium aluminum silicate in pharmaceutics was reviewed in this paper. We introduced the physiochemical properties and safety profile evaluations of magnesium aluminum silicate firstly. Then the research progress of the application of magnesium aluminum silicate was reviewed from the following five aspects: firstly, improving the fluidity of powder, increasing the hardness of tablets as well as preventingpowder from moisture caking; secondly, powdering oil-like drugs; thirdly, grinding poorly water-soluble crystalline drugs with magnesium aluminum silicate to form amorphous products, which can improve the dissolution rate of the drugs. In addition, the paper also reviewed the applications of magnesium aluminum silicate in solid dispersions, designing of sustained release formulations and so on.
