Metabolomics Study on the Treatment of CFS Model Rats with Schisandra chinensis Polysaccharide

Author: Ai-Ping CHI ¹
Author Information

1. Key Laboratory of Medicinal Resources and Natural Medicinal Chemistry of Ministry of Education, Shaanxi Normal University
Publication Type:Journal Article
Keywords: Chronic fatigue syndrome; Metabonomic; Schisandra chinensis polysaccharide
From: Chinese Pharmaceutical Journal 2017;52(5):391-397
CountryChina
Language:Chinese
Abstract: OBJECTIVE: To investigate the therapeutic effects metabolic mechanism of Schisandra chinensis polysaccharide (SCP) on chronic fatigue syndrome (CFS). METHODS: CFS rat model was established in a variety of ways such as the bondage, excessive exercise, crowded and noise environment. The Morris water maze test, the open-field test and the tail-suspension test were performed to evaluate the CFS model. The gas chromatography-mass spectrometry (GC-MS) method was conducted to screen the different metabolites in rat urine and analyze the metabolic pathway. RESULTS: The body weight of rats were increased and their space exploration and memory ability were strengthened after SCP supplement. The eleven diversity urine metabolites were detected and the involved metabolic pathways were the tricarboxylic acid cycle and the alanine, aspartic and glutamic acid metabolic pathways. CONCLUSION: SCP could relieve the chronic fatigue syndrome. The metabolic mechanism is relative to the improvement of SCP on the tricarboxylic acid cycle and the alanine, aspartic and glutamic acid metabolic pathways.