A New Iridoid glucoside from the Ripe Fruits of Cornus officinalis Sieb. et Zucc.
- Author:
Hao-Yi QIAO
1
Author Information
- Publication Type:Journal Article
- Keywords: 6'-O-acetyl-7β-O-ethyl morroniside; Cornus officinalis; Iridoid glucoside; PC12 cell
- From: Chinese Pharmaceutical Journal 2017;52(14):1212-1216
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To study the chemical constituents from the ripe fruits of Cornus officinalis Sieb. et Zucc., and evaluate their protection on PC12 cells exposed to oxygen and glucose deprivation. METHODS: The compounds were isolated through various chromatographic methods including macroporous adsorption resin, silica gel, ODS, Sephadex LH-20 column chromatography, and preparative HPLC, and their structures were determined through spectroscopic analysis, including 1D and 2D NMR and MS data. RESULTS: Eight compounds were isolated from the water extract of the ripe fruits of Cornus officinalis Sieb. et Zucc., and their structures were elucidated as 6'-O-acetyl-7β-O-ethyl morroniside (1), chrysoderol(2), luteolin(3), 5-hydroxymethylfurfural(4), syringate(5),p-hydroxybenzoic acid(6), caffeic acid methyl ester(7), ethyl gallate(8). CONCLUSION: Compound 1 is a new iridoid glucoside, and compounds 2, 3, 5, 7 are obtained from Cornus officinalis for the first time. The MTT results show that compound 4 moderately increases the viability of OGD/R treated PC12 cells at the concentration of 1.0 μmol·L-1.
