Preparation and Rheological Property of Cross-Linked Sodium Hyaluronate Gel
- Author:
Qian-Qian CHEN
1
Author Information
- Publication Type:Journal Article
- Keywords: 1, 4-butanediol diglycidyl ether rheological property viscoelasticity; Creep recovery; Cross-linked sodium hyaluronate gel
- From: Chinese Pharmaceutical Journal 2017;52(15):1342-1346
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To prepare crossed-linked sodium hyaluronate (CHA) gel and study its rheological property. METHODS: CHA was prepared using 1, 4-butanediol diglycidyl ether (BDDE). The linear viscoelastic properties and creep recovery of hyalouronan(HA) and CHA were measured with a rheometer. The influencing factors of rheological properties were analyzed, such as concentration, proportion of cross-linker and temperature. RESULTS: Cross-linked sodium hyaluronate gel was prepared. The viscoelasticity was measured with a pair of 20 mm stainless steel plates at the frequency of 1 Hz and shear-strain of 1 Pa at (25±0.1)℃. As shown by the creep recovery test, CHA had a smaller strain and shorter time to recover to the minimum strain than HA, which showed typical linear viscoelastic and creep recovery properties. CONCLUSION: CHA is a non-Newtonian fluid, which is easy to administer and conforms completely to the requirements for viscoelastic supplementation materials for intra-articular injection. Compared with HA, CHA has more advantageous viscoelastic property and stability.
