A Case of Acute Hepatitis B by Occult HBV Infection without HbsAg Seroconversion.
- Author:
Hye Mi JUNG
1
;
Dae Won JUN
;
Ji Yeon MIN
;
Eun Young DOO
;
Kil Woo NAM
;
Young Il KWON
;
Oh Wan KWON
Author Information
1. Department of Internal Medicine, Hanyang University School of Medicine, Seoul, Korea. noshin@hanyang.ac.kr
- Publication Type:Case Report
- Keywords:
Hepatitis B Surface Antigens;
Hepatitis B;
Rituximab
- MeSH:
Antibodies, Monoclonal, Murine-Derived;
Hepatitis;
Hepatitis B;
Hepatitis B Surface Antigens;
Hepatitis B virus;
Humans;
Rituximab
- From:Korean Journal of Medicine
2012;83(5):619-623
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Many studies have recently reported reactivation in hepatitis B surface antigen (HBsAg)-negative subjects with the use of biologic agents such as rituximab. However, occult hepatitis B virus infection itself has little clinical impact. We experienced a case of acute exacerbation caused by occult hepatitis B infection without HBsAg seroconversion. No mutation was found on the major hydrophilic loop of the S protein. The patient recovered from acute exacerbation after antiviral therapy. In conclusion, acute exacerbation can be induced by occult hepatitis B virus infection itself without reactivation. In such a case, antiviral therapy should be considered.
