Preliminary Study on Stability and Pharmacokinetics of Chitosan-Modified L-asparaginase Liposomes
- Author:
Sheng-Li WAN
1
Author Information
- Publication Type:Journal Article
- Keywords: Chitosan; L-asparaginase; Liposome; Pharmacokinetics; Stability
- From: Chinese Pharmaceutical Journal 2017;52(19):1706-1709
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To investigate the stability and pharmacokinetics of chitosan-modified L-asparaginase liposomes. METHODS: The activities of L-asparaginase and chitosan-modified L-asparaginase liposomes in blank rat plasma were determined at different time. L-asparaginase and chitosan-modified L-asparaginase liposomes were intravenously injected to rats through tail vein. The pharmacokinetic parameters were calculated by DAS. RESULTS: The activity of chitosan-modified L-asparaginase liposomes in plasma was significantly higher than that of L-asparaginase. The AUC0-48 h of chitosan-modified L-asparaginase liposomes was as 3.3 times as that of L-asparaginase. And the MRT0-48 h of chitosan-modified L-asparaginase liposomes was as 2.3 times as that of L-asparaginase. CONCLUSION: Chitosan-modified L-asparaginase liposomes can improve the stability and bioavailability of L-asparaginase.
