Anti-Inflammatory Action and Mechanism on the Adjuvant Arthritis Mouse Model of Petroleum Ether Extract from Citrullus lanatus Vine

Author: Xiao-Mei GONG ¹
Author Information

1. National Engineering Laboratory of Southwest Endangered Medicinal Resources Development, Institute of Guangxi Medicinal Plant
Publication Type:Journal Article
Keywords: Adjuvant arthritis; Citrullus lanatus vine; Mechanism; Petroleum ether extract
From: Chinese Pharmaceutical Journal 2017;52(19):1680-1684
CountryChina
Language:Chinese
Abstract: OBJECTIVE: To study the pharmacological function of the petroleum ether extract from Citrullus lanatus vine (PEECLV) in treating adjuvant arthritis(AA) and explore the mechanism. METHODS: AA in mice was made to observe the anti-inflammatory effect of PEECLV. Arthritis index was calculated by 5 grades evaluation. Thymus and spleen index were measured. The content of RF, PGE2, COX-1, COX-2 in serum were measured. The levels of TNF-α, IL-1β in serum were measured. RESULTS: PEECLV can suppress the foot swelling degree in model mice. It can increase thymus index, reduce spleen index and AI of AA in mice. High-dose group can significantly reduce serum PGE2, IL-1β, COX-2 and COX-1 levels in AA in mice. All groups can reduce TNF-α and RF levels. CONCLUSION: PEECLV has a certain degree therapeutic effect on AA, and the possible mechanism is to affect the production of inflammatory mediators and antioxidant.