Effects and Mechanisms of Large Plant Rhodiola Tablet on Acute Myocardial Ischemia of Rats
- Author:
Zhuo-Qiong LI
1
Author Information
- Publication Type:Journal Article
- Keywords: Large plant Rhodiola; Myocardial ischemia; Oxidative stress
- From: Chinese Pharmaceutical Journal 2017;52(22):1993-1997
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To study the effect and action mechanism of the large plant Rhodiola Tablet on myocardial ischemia of rats. METHODS: Rat myocardial ischemia models were induced by coronary artery ligation. The levels of AST, ALT, CK and CK-MB in serum were observed, at the same time the expressions of B-raf, Ras and p-ERK1/2 in myocardial tissue were determined. RESULTS: The levels of AST, ALT, CK and CK-MB in rat serum, as well as the B-raf, Ras and p-ERK1/2 expression in rats myocardium in the large plant Rhodiola group were significantly lower than that in the model group. CONCLUSION: Large plant Rhodiola has a certain antagonism on myocardial ischemia injury in rats caused by coronary artery ligation. The mechanism of action may be related to the decreases in serum AST, ALT, CK and CK-MB, as well as myocardial high expression of the B-raf, Ras and p-ERK1/2.
