Evaluation of Therapeutic Regimens of Biapenem Against Acinetobacter Baumannii Infection in ICU Subjects by Monte Carlo Simulation
- Author:
Jian-Guo ZHU
1
Author Information
- Publication Type:Journal Article
- Keywords: ABA; Biapenem; Monte Carlo simulation; Two-steps infusion therapy
- From: Chinese Pharmaceutical Journal 2017;52(24):2218-2222
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To provide the basis for biapenem against Acinetobacter baumannii infection in ICU patients in our hospital. METHODS: One hundred-five strains of ABA were collected. The MICs of biapenem against bacteria were measured by double broth dilution method. Four therapeutics regimens (0.3 g, q12 h; 0.3 g, q8 h; 0.3 g, q6 h; 0.6 g, q12 h) in traditional short-time infusion, extended infusion(3, 4h) and two-step infusion(1.5-5.5 h) were simulated by using the Monte Carlo simulation, then the PTAs and CRFs were calculated. RESULTS: CFRs of all treatments of biapenem against ABA infection in ICU subjects were <90%; but for non MDR-ABA, all biapenem regimens' CFR were >90% except biapenem 0.3g, q12 h(0.5 h) and 0.3 g, q12 h (two-step infusion for 1.5h). PTAs of the whole regimens were >90% when MIC≥2 mg·L-1. Extended infusion and two-step infusion got the similar PTAs and CFRs with a similar time when the regimens obtained target, more than short infusion obviously. CONCLUSION: Biapenem alone should avoid for ABA infection as expiry therapy in ICU population in our hospital. Extended infusion and two-step infusion should be priority selection as target therapy according to sensitivity test.
