Anticoagulation Effect and Bleeding Risk of Combination Therapy with SAFI and Aspirin
- Author:
Shi-Han GENG
1
Author Information
- Publication Type:Journal Article
- Keywords: Aspirin; Bleeding risk; Combination therapy; Salvianolate injection (SAFI)
- From: Chinese Pharmaceutical Journal 2018;53(1):35-39
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To explore the curative effect of combination therapy with salvianolate injection (SAFI) and aspirin on anti-platelet aggregation and blood coagulation function, provide the experimental evidence for clinical consequence use of combination therapy with traditional Chinese medicine and western medicine. METHODS: The bleeding time was measured by cutting tail evaluating of combination of drugs; platelet maximum aggregation rate induced by ADP, AA, collagen and thrombin in rats was determined by absorbance method using a microplate reader; blood coagulation of the four indicators were measured by the semiautomatic blood agglutination instrument. RESULTS: SAFI had nearly no effects on aspirin group's bleeding time. The effect on blood platelets aggregation compared with control group, SAFI group and aspirin group could significantly reduce platelet aggregation induced by ADP, AA, collagen and thrombin in normal rats(P<0.01). Combinative group could significantly increase aspirin group's anti-platelet aggregation induced by ADP, AA, collagen and thrombin in normal rats(P<0.01, P<0.05). Coagulation function SAFI can reduced aspirin group's TT after the combination therapy. CONCLUSION: SAFI can increase anticoagulation effect of aspirin, and have no effect on aspirin's bleeding risk.
