Discussion of the Correlation between Voriconazole's Trough Concentration and Mental Abnormity Rate
- Author:
Ting-Ting DAI
1
Author Information
- Publication Type:Journal Article
- Keywords: Adverse drug reaction; Mental abnormity; Trough concentration; Voriconazole
- From: Chinese Pharmaceutical Journal 2018;53(5):375-378
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To explore the correlation between voriconazole's trough concentration and mental abnormity. METHODS: Retrospectively analyze voriconazole's trough concentration and the occurrence of mental abnormity in 151 patients from May 2016 to May 2017 in Xiangya Hospital. RESULTS: In 151 patients, Insomnia rate is 21.85%, binary logistic regression analysis showd that the insomnia rate is positively related to voriconazole's trough concentration(P = 0.02). Illusion rate is 15.23%, binary logistic regression analysis showd that the illusion rate is positively related to voriconazole' s trough concentration (P = 0.002). CONCLUSION: There is a significant correlation between voriconazole's mental abnormity and trough concentration.
