The Curative Effect of Shugan Granule in the Treatment of Post-stroke Depression and Effect on BDNF and Inflammatory Factors
- Author:
Xiao-Xi LIU
1
Author Information
- Publication Type:Journal Article
- Keywords: BDNF; Curative effect; Inflammatory factor; Post-stroke depression; Shugan granule
- From: Chinese Pharmaceutical Journal 2018;53(13):1140-1144
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To investigate the curative effect of Shugan granule in the treatment of post-stroke depression (PSD) and effect on brain devived neurotrophic factor(BDNF) and inflammatory factors. METHODS: Eighty Patients with PSD were randomly divided into control group and study group, 80 cases in each group. Besides routine treatment, control group received citalopram hydrobromide 20 mg•d-1. Study group received Shugan granule 1 bags•time-1, twice a day based on control group.8 weeks for a course of treatment. HAMD scores, BI index, BDNF and inflammatory factors levels were compared. RESULTS: The total effective rate in study group was significantly higher than that in control group[71 cases,88.75% vs 61 cases, 76.25%, χ2=4.329, P<0.05]. Repeated measurement data analysis of variance showed, the overall scores of HAMD in study group were significantly lower than those in control group [Fgroup=36.541, P<0.05]. The HAMD scores of the two groups decreased with the extension of treatment time [Ftime=668.574, P<0.05].The reduction extent of HAMD score in study group was significantly higher than that in control group[Fgroup×time=18.495, P<0.05]. BI indexes and BDNF levels in study group were significantly higher than those in control group [Fgroup=48.147, 41.561, P<0.05]. BI indexes and BDNF levels of two groups increased with the extension of treatment time [Ftime=316.586, 595.864, P<0.05]. The increasing extent of BI indexes and BDNF levels in study group was significantly higher than that in control group [Fgroup×time=22.849, 10.515, P<0.05]. The overall levels of TNF-α, IL-6 and hs-CRP in study group were significantly lower than those in control group [Fgroup=117.849, 85.168, 66.763, P<0.05]. TNF-α, IL-6 and hs-CRP levels of two groups decreased with the extension of treatment time [Ftime=864.584, 697.717, 1 037.167, P<0.05]. The reduction extent of TNF-α, IL-6 and hs-CRP levels in study group was significantly higher than that in control group[Fgroup×time=31.271, 26.174, 17.585, P<0.05]. There was no significant difference in adverse reactions between the two groups [9 cases, 11.25% vs 15 cases, 18.75%, χ2=1.765, P>0.05]. CONCLUSION: On the basis of conventional western medicine treatment, Shugan granules can improve the degree of depression and reduce the level of inflammatory factors in patients with PSD.
