New Carrier Materials for Particles Drug Delivery System of Irinotecan Hydrochloride
- Author:
Sheng-Qi DENG
1
Author Information
- Publication Type:Journal Article
- Keywords: Amphiphilic block copolymer; Irinotecan hydrochloride; Micellar drug delivery system; Phospholipid compound
- From: Chinese Pharmaceutical Journal 2018;53(13):1093-1097
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To prepare micelle drug delivery system of irinotecan hydrochloride, which could reduce its side effects and improve the therapeutic effects. METHODS: Firstly, the irinotecan hydrochloride was prepared as phospholipid compound to improve the lipophilicity. The synthesized polycaprolactone-polyethylene glycol copolymer was used as carrier material, then the phospholipid complex of irinotecan hydrochloride was wrapped to prepare a polymer micelle drug delivery system. The optimum prescription and preparation process of micelle drug delivery system of irinotecan hydrochloride were screened by the method of single factor combined with orthogonal test. RESULTS: The liposoluble of phospholipid compound of irinotecan hydrochloride was obviously increased compared with active compound. The irinotecan hydrochloride micelle was spherical and its particle size distribution was uniform. The average entrapment efficiency was 61.32%, and the average drug loading was 2.88%. CONCLUSION: Through this method, the particle size of irinotecan hydrochloride is small and the quality is controllable, and it is hopeful to increase the drug concentration at the target site.
