Overview of the Quality Study on Hydroxyethyl Starches
- Author:
Xiang-Mei ZHAO
1
Author Information
- Publication Type:Journal Article
- Keywords: Assay; C2/C6; Hydroxyethyl starch; Molar substitution; Quality control
- From: Chinese Pharmaceutical Journal 2018;53(13):1047-1051
- CountryChina
- Language:Chinese
- Abstract: Hydroxyethyl starches(HES) are modified natural polymer of amylopectin with volume expansion properties. It has been widely used in the treatment for prevention of hypovolemia and acute normovolemic hemodilution(ANH). However, the potential threats to kidney and coagulation have attracted much attention and controversy in recent years. This review will focus on the specification development and quality study of HES. The article will mainly talk about some quality control items: molecular weight (Mw) and molecular weight distribution, degree of hydroxyethyl (molar substitution, MS), the specific sites of hydroxyethylation (C2/C6 ratio) and assay, all of those are based on the domestic enterprise standards and Europe Pharmacopoeia(EP), and we will combine with the experimental data to give some suggestions on these items quality control. Hopefully to provide some ideas for improving and unifying the quality standard of hydroxyethyl starches.
