Chemical Constituents from the Root Bark of Celastrus monospermus
- Author:
Ming-Xiang CHEN
1
Author Information
- Publication Type:Journal Article
- Keywords: Celastrus monospermus; Chemical constituent; Friedelane; Root bark
- From: Chinese Pharmaceutical Journal 2018;53(15):1265-1272
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To study the chemical constituents from the root bark of Celastrus monospermus Roxb. METHODS: The compounds were isolate and purified by repeated column chromatography on silica gel, ODS and Sephadex LH-20, and the chemical structures of compounds were determined by spectral data analyses. RESULTS: Twenty-three compounds were isolated from this plant, which were identified as β-sitosterol palmitate (1), friedelan-3-one (2), 3β-hydroxyolean-12-en (3), 3β-hydroxylcholest-5,22-dien (4), β-sitosterol (5), 3,22-dioxo-20-taraxastene (6), 3,12-dioxofriedelane (7), 3-oxo-28-hydroxyfriedelane (8), 3-oxo-11β-hydroxyfriedelane (9), 3-oxo-12α-hydroxyfriedelane (10), pristimerin(11), 3-oxo-30-hydroxyfriedelane (12), 3-oxo-29-friedelanoic acid (13), salaspermic acid (14), celastrol (15), 3β, 21β-dihydroxy-30-nor-friedelan-20(29)-en-27-oic acid (16), 3β, 22α-dihydroxy-olean-12-en-29-oic acid (17), wilforol A (18), orthosphenic acid (19), p-hydroxybenzoic acid (20), 3-oxo-2β-hydroxyfriedelan-29-oic acid (21), 21-oxo-2α,3α,22β-trihydroxy-29-nor-friedelan-24,2β-lactone (22)and daucosterol (23). CONCLUSION: Compounds 1,6, 13-14,16-22 are obtained from this plant for the first time, and compounds 16, 20-22 are isolated from the genus Celastrus for the first time.
