Adamts-7—a new target for cardiovascular diseases treatment
- Author:
Song YANG
1
Author Information
- Publication Type:Journal Article
- Keywords: ADAMTS-7; Cardiovascular diseases; COMP; Metalloproteinase
- From: Chinese Pharmaceutical Journal 2018;53(18):1536-1540
- CountryChina
- Language:Chinese
- Abstract: A disintegrin-like and metalloprotease(ADAMTS) proteinases are a group of multidomains and secreted metalloproteinases containing the thrombospondin motifs. ADAMTS-7 is a member of ADAMTS family and plays a crucial role in the cardiovascular diseases. In physically, ADAMTS-7 was involved in the growth and development of the body. However, in pathological conditions, over expression of ADAMTS-7 gene accelerated the progression of cardiovascular diseases through by promoting the breakdown of cartilage oligomeric matrix protein (COMP) matrix. Meantime, the over expression of ADAMTS-7 can be effectively inhibited by TGF-β, miRNA29a/b, and then effectively retarded the development of cardiovascular disease. This article mainly reviews the gene structure, protein function and the mechanism of ADAMTS-7 involved in cardiovascular diseases and looks forward to the possibility of ADAMTS-7 as a new target for the treatment of cardiovascular diseases.
