Preparation Technology of Standard Decoction and Formula Granules of Moutan Cortex Containing Volatile Components
- Author:
Hui-Jie JIANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Fingerprint; Formula granule; Moutan Cortex; Paeonol; Preparation process; Standard decoction
- From: Chinese Pharmaceutical Journal 2018;53(21):1869-1875
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To establish the preparation technology of Moutan Cortex standard decoction and formula granules. METHODS: Moutan Cortex standard decoction was prepared by decocting pot and the parameters and fingerprints of 15 batches of decoction were established.To improve the preparation process of Moutan Cortex formula granules, paeonol was quickly recovered by using volatile oil collection device in the process of vacuum concentration, and the collected paeonol was added back to the concent rated solution.Then, the formula granules of Moutan Cortex were prepared by spray drying and dry granulating.The correlation between the decoction pieces, extract, concentrate, powder, formula granules and standard decoction were compared by taking the contents of paeoniflorin, paeonol and fingerprint as indexes. RESULTS: The range of parameters for Moutan Cortex standard decoction(70%-130% of the average value) were as follows:the dry extract rate was 19.46%-36.14%. The content of paeoniflorin was in the range of 1.83%-3.40%, and the transfer rate was 60.32%-100.00%. The content of paeonol was 1.25%-2.33%, and the transfer rate was 14.42%-26.78%.The contents of paeoniflorin and paeonol in the formula granules of Moutan Cortex conformed to the range of standard decoction parameters. CONCLUSION: The parameters of Moutan Cortex standard decoctions prepared by decocting pot are confirmed, and a new preparation process of Moutan Cortex formula granules is established.Both of standard decoction and formula granules have good consistency in the contents of the index components,which could provide a certain scientific basis for the guidance of actual production.
