Research Progress in Synaptic Plasticity Impairment of Diabetic Encephalopathy
- Author:
Hua-Jing YIN
1
Author Information
- Publication Type:Journal Article
- Keywords: AMPARs; Diabetic encephalopathy; LTP/LTD; NMDARs; Potassium channels; Synaptic plasticity
- From: Chinese Pharmaceutical Journal 2018;53(21):1805-1809
- CountryChina
- Language:Chinese
- Abstract: Previous studies demonstrate that diabetes mellitus induces cognitive impairment,leading to diabetic encephalopathy(DE), which is closely related with hippocampal synaptic plasticity impairment,including synaptic structural and functional damage. Structural damage mainly embodied in the synapse degeneration.Functional damage mainly reflects in the LTP damage, including the composition variation and functional lesions of N-methyl-D-aspartate receptors(NMDARs), α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) and patassium channels.Abnormal synaptic plasticity may be critical in the pathogenesis of diabetic encephalopathy. In this review, we summarized the relationship between DE and synaptic plasticity impairment.
