Research Advance of Effective Components of Traditional Chinese Medicine on Alleviating Acetaminophen-Induced Liver Injury
- Author:
Hao-Nan RUAN
1
Author Information
- Publication Type:Journal Article
- Keywords: Acetaminophen; Flavonoids; Liver injury; Polyphenols; Protective effect; Traditional Chinese medicine
- From: Chinese Pharmaceutical Journal 2019;54(2):81-85
- CountryChina
- Language:Chinese
- Abstract: Acetaminophen (APAP) is one of the commonly used analgesic antipyretic anti-inflammatory drugs, which cause drug-induced liver damage and even acute liver failure due to take large amounts of drugs blindly, combination drugs-using or long-term medication. The mechanisms of APAP-induced hepatotoxicity mainly focus on the generation of toxic metabolites, mitochondrial dysfunction, inflammatory response, oxidative stress, the release of damage associated molecular patterns (DAMPs), autophagy, endoplasmic reticulum stress, and microcirculatory dysfunction. This article summarizes the toxic mechanism of drug-induced liver injury induced by APAP, and summarizes the research progress of active ingredients of traditional Chinese medicine on the protective effect of APAP-induced liver injury, including polyphenols, flavonoids, saponins, organic acids, terpenoids, phenylpropanoids compounds, sugars, alkaloids and other compounds, to provide a reference for the development of drugs to prevent and treat APAP-induced liver injury.
