Progress of multi-target directed drugs based on tacrine and donepezil in alzheimer′s disease
- Author:
Ke-Ren WANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Alzheimer′s disease; Donepezil; Multi-target directed ligands; Tacrine
- From: Chinese Pharmaceutical Journal 2019;54(5):352-359
- CountryChina
- Language:Chinese
- Abstract: Alzheimer′s disease (AD) is a progressive multifactorial neurodegenerative disorder in elder people. Currently, the pathogenesis of AD is unclear, and it is presently incurable. In view of the complex network pathological features of AD, a single small molecule compound that can act simultaneously with multiple targets, called multi-target directed ligands (MTDLs), is considered to be an effective therapeutic strategy at present. Here, we review highlights recent MTDLs approach based cholinesterase inhibitors, antioxidant, metal chelator and neuroprotectant in the novel drug candidate prototypes for the treatment of AD.
