Determination of Teicoplanin in Human Plasma and Related Factors Analysis
- Author:
Rong-Ge ZHANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Creatine clearance; Hypersensitive C-reactive protein; Plasma concentration; Teicoplanin
- From: Chinese Pharmaceutical Journal 2019;54(8):654-658
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To investigate the related factors effecting the teicoplanin concentration..METHODS: The patients′ information who accepted teicoplanin therapy and their plasma on the fourth day treatment were collected. The plasma was processed and detected by HPLC method. A multiple linear regression method was used to explore the relationship between the teicoplanin concentration and other factors. RESULTS: The result of multiple linear regression shows that the teicoplanin concentration relates with the creatine clearance and hypersensitive C-reactive protein. CONCLUSION: The teicoplanin treatment regimen could be altered by the level of patients′ creatine clearance and hypersensitive C-reactive protein in order to deliver a better individual treatment.
