Correlation Study between CYP2C8 Gene Polymorphim and Adverse Reaction of Paclitaxel in Cancer Patients
- Author:
Qiu-Xia XU
1
Author Information
- Publication Type:Journal Article
- Keywords: Adversereaction; CYP2C8; Geneticpolymorphism; Paclitaxel
- From: Chinese Pharmaceutical Journal 2019;54(12):1007-1011
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To investigate the correlation between CYP2C8 gene polymorphisms and the adverse reactions of paclitaxelin in cancer patients.METHODS: Fifty-two patients who received paclitaxel chemotherapy from January 2016 to May 2018 were selected as experimental subjects. The CYP2C8 genotypes of the selected patients were tested and the adverse reactions of paclitaxel were observed, collected and recorded to explore the relationship between adverse reactions and genetic polymorphism.RESULTS: In this study, 25 gene loci were detected, only 7 gene loci had mutation, and the remaining 18 gene loci were all wild-type.In the polymorphism of CYP2C8 gene,the incidence of thrombocytopenia and pain in patients with CYP2C8*1B(-271C>A) wild-type (CC) was significantly higher than that in mutant (CA+AA) (P<0.05). And the incidence of hepatotoxicity in patients with CYP2C8*2/*3(32299C>T) wild-type gene (CC) was significantly lower than that in mutant gene (CT+TT) (P<0.05).CONCLUSION: The polymorphism of CYP2C8 gene may be associated with the adverse reaction of paclitaxel.
