Increased Nasal Interleukin-33 in the Infants with Acute Respiratory Syncytial Virus Bronchiolitis.
10.7581/pard.2012.22.4.383
- Author:
Seung Ho YANG
1
;
Mi Ae CHU
;
Hye Jin PARK
;
Kye Hyang LEE
;
Woo Taek KIM
;
Hai Lee CHUNG
Author Information
1. Department of Pediatrics, Catholic University of Daegu School of Medicine, Daegu, Korea. hlchung@cu.ac.kr
- Publication Type:Original Article
- Keywords:
Interleukin-33;
Iinterleukin-33 receptor;
Respiratory syncytial virus;
Bronchiolitis;
Infant
- MeSH:
Anoxia;
Bronchiolitis;
Enzyme-Linked Immunosorbent Assay;
Humans;
Immunity, Mucosal;
Immunoglobulin E;
Immunoglobulins;
Infant;
Inflammation;
Interleukin-1;
Interleukins;
Length of Stay;
Lung;
Oxygen;
Respiration;
Respiratory Syncytial Viruses;
Skin;
Thoracic Wall
- From:Pediatric Allergy and Respiratory Disease
2012;22(4):383-389
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Interleukin (IL)-33, a member of the IL-1 cytokine family, is considered to be important for innate-type mucosal immunity of the lung and also has been suggested to induce Th2-type immune responses. We aimed to investigate if IL-33 is involved in airway inflammation due to respiratory syncytial virus (RSV) infection in young children. METHODS: Thirty-eight infants (< or =24 months of age) admitted with their first episode of RSV bronchiolitis were enrolled in the study. Atopy was defined by having at least 1 allergen-specific immunoglobulin E (IgE), positive result to skin prick test, or high serum IgE levels. The patients were assessed to have severe symptoms when they had > or =2 of the following clinical findings: hypoxemia (<92% oxygen saturation), rapid breathing (and/or lower chest wall indrawing), and >7 days of hospital stay. The levels of IL-33 and the IL-33 receptor (sST2) were measured using enzyme-linked immunosorbent assay in nasal secretion samples collected from the patients on admission and compared with 20 age-matched controls. We also investigated the levels of IL-33 and sST2 in relation to the atopic status and symptom severity of the patients. RESULTS: Nasal IL-33 levels in the patients with acute RSV bronchiolitis were significantly increased (P<0.05), but sST2 showed no difference compared to the controls. Neither IL-33 nor sST2 showed significant difference in relation to the atopic status or severity of symptoms. CONCLUSION: Our study showed significantly increased IL-33 in the nasal secretions of the young infants admitted with acute RSV bronchiolitis and suggests that IL-33 is involved in the pathogenesis of RSV-induced airway inflammation.
