Stability Study of Baicalein-7-O-diglucoside
- VernacularTitle: 中药化学对照品木蝴蝶苷B的稳定性研究
- Author:
Xiao-Ru HU
1
Author Information
- Publication Type:Journal Article
- Keywords: 7-methoxy baicalein; Baicalein; Baicalein-7-O-diglucoside; Stability
- From: Chinese Pharmaceutical Journal 2020;55(2):90-95
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To investigate the stability of baicalein-7-O-diglucoside. METHODS: The chromatographic purity of baicalein-7-O-diglucoside and its solution in different condition was analyzed by HPLC-DAD. The degradation products of baicalein-7-O-diglucoside in its solvent were identified by LC-MS. Three degradation products in the solvent of baicalein-7-O-diglucoside were identified with applying electrospray ionization(ESI) source in the positive ion mode.RESULTS: ① Baicalein-7-O-diglucoside was stable with light and in 40, 80 and 105 ℃ within the inspection time in solid state. ②Baicalein-7-O-diglucoside in water was stable in room temperature and degrades quickly in 50%methanol and 50% ethanol. ③The degradation products of baicalein-7-O-diglucoside in solvent were 7-methoxy baicalein, 7-ethoxy baicalein and baicalein. The above research provides that baicalein-7-O-diglucoside is stable in solid state. Baicalein-7-O-diglucoside degrades in 50% methanol and 50% ethanol. CONCLUSION: Water should be used as the solvent for solution of baicalein-7-O-diglucoside. The solution of baicalein-7-O-diglucoside should be made up before use or stored in the refrigerator immediately after preparation.
