Research Advances on Non-Clinical Evaluation in Vitro of Drug-Induced Arrhythmias
- VernacularTitle: 药物诱导的心律失常非临床体外评价研究进展
- Author:
Dong-Sheng PAN
1
Author Information
- Publication Type:Journal Article
- Keywords: Action potential; Drug-induced arrhythmia; Field potential; HERG blocking; Human induced pluripotent stem cell-derived cardiomyocytes; Torsade de pointes
- From: Chinese Pharmaceutical Journal 2020;55(13):1053-1059
- CountryChina
- Language:Chinese
- Abstract: Drug-induced arrhythmia is one of the main causes of failure in drug development, and it is also a major cause of drug withdrawal, therefore, accurate prediction of drug-induced arrhythmia in the non-clinical research stage is the best way to reduce cost. Literature was retrieved by formally searching PubMed, Metstr, CNKI and Baidu Scholar, 1 479 published articles were found through search method, 63 full-text articles were included. After reviewed the relevant literatures, the advantages and disadvantages of the different experimental cells and the related evaluation methods are assessed, in order to provide reference for toxicity evaluation.
