Chemical Constituents of the Roots of Astragalus acaulis
- VernacularTitle: 无茎黄芪根的化学成分研究
- Author:
Ying-Zhi CHEN
1
Author Information
- Publication Type:Journal Article
- Keywords: Astragalus acaulis; Flavonoid; Lignan; Root; Steroid
- From: Chinese Pharmaceutical Journal 2020;55(15):1253-1258
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To study the major chemical constituents of the roots of Astragalus acaulis. METHODS: Compounds were isolated and purified by using silica gel, Sephadex LH-20, and Rp-18 chromatographic techniques. Their structures were determined based on various spectral analysis and physicochemical properties. RESULTS: Ninteen compounds were obtained from ethyl acetate and n-butanol fractions derivated from the methanol extract of the roots of A. acaulis, and identified as liquiritigenin (1), isoliquiritigenin (2), isomucronulatol (3), syringaresinol-4-O-β-D-glucopyranoside (4), lariciresinol (5), lariciresinol-4-O-β-D - glucopyranoside (6), 5-methoxylariciresinol-4-O-β-D-glucopyranoside (7), p-hydroxybenzaldehyde (8), sorbitol (9), 7-oxositosterol (10), 7β-hydroxysitosterol (11), β-sitosteryl-D-glucoside-6'palmitate (12), 5α, 8α-epidioxy-ergosta-6, 22E-dien-3β-ol (13), 2α, 3β-dihydroxyloleanolic acid (14), methyl stearate (15), β-sitosterol (16), daucosterol (17), oleic acid (18), and methyl elaidate (19). CONCLUSION: All of the compounds reported in this study are isolated from the plant for the first time. A. acaulis is rich in flavonoids, lignans, and steroids.
