Therapeutic Drug Monitoring and Individualized Medication of Ribavirin
- VernacularTitle: 利巴韦林的治疗药物监测与个体化给药概述
- Author:
Zhi-Yuan TAN
1
Author Information
- Publication Type:Journal Article
- Keywords: COVID-19; Individualized medication; Population pharmacokinetics; Ribavirin; Therapeutic drug monitoring
- From: Chinese Pharmaceutical Journal 2020;55(15):1229-1233
- CountryChina
- Language:Chinese
- Abstract: Ribavirin is a widely used nucleoside antiviral drug. During the epidemic of coronavirus disease 2019 (COVID-19), ribavirin was recommended for empirical treatment in the Clinical Management of Human Infection with COVID-19 (trial guidance v6). However, due to the large inter-individual variations in dose-response relationship, and extremely long terminal half time, it is necessary to perform therapeutic drug monitoring and individualized dose adjustment for ribavirin in special populations. In this article, the pharmacokinetics and therapeutic drug monitoring of ribavirin in different populations are reviewed in order to provide reference for clinical rational use and individualized medication of ribavirin for treatment of COVID-19.
