Taste-Masking Effect of Montelukast Sodium Orally Disintegrating Tablets Using Electronic Tongue Analysis and Human Sensory Evaluation Method
- VernacularTitle: 应用电子舌和感官评定方法考察孟鲁司特钠口崩片的掩味效果
- Author:
Chao-Xing HE
1
Author Information
- Publication Type:Journal Article
- Keywords: Electronic tongue; Linear discriminant analysis; Montelukast sodium; Orally disintegrating tablet; Principal component analysis; Sensory evaluation
- From: Chinese Pharmaceutical Journal 2020;55(16):1354-1357
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To investigate the taste-masking effect of montelukast sodium orally disintegrating tablets using electronic tongue technology and human sensory evaluation and determine the optimum formulation. METHODS: Orally disintegrating tablets were prepared with five different concentrations of flavoring agents or without flavoring agent.The tastes of those tablets were determined by electronic tongue, and principal component analysis and linear discriminant analysis were used to evaluate differences of different formulations. The taste-masking effect of the tablets was investigated combined with electronic tongue analysis and sensory evaluation of subjects. RESULTS: The taste of orally disintegrating tablet was the best when the total amount of flavoring agent was 1.6 mg, and the ratio of sweetening agent to aromatic agent was 5∶3. CONCLUSION: The combination of electronic tongue and human sensory assess can evaluate the taste-masking effect of orally disintegrating tablets and provide the basis for determining the optimum formulation.
