Progress in Molecular Mechanisms and Cell Transplantation Therapy of Parkinson's Disease
- VernacularTitle: 帕金森病的分子机制及细胞移植治疗进展
- Author:
Feng-Xia SHAO
1
Author Information
- Publication Type:Journal Article
- Keywords: Cell transplantation therapy; Dopaminergic neuron; Molecular mechanism; Parkinson's disease; Reprogramming
- From: Chinese Pharmaceutical Journal 2020;55(18):1487-1491
- CountryChina
- Language:Chinese
- Abstract: Neuron is the basic structure and functional unit of nervous system. Once the neurons are damaged or lost, the balance of neuroregulation will be destroyed and a series of nervous system diseases will be induced. Parkinson's disease (PD) is a kind of chronic neurodegenerative disease caused by selective loss of many dopaminergic neurons in the dense region of the substantia nigra in the ventral midbrain. At present, conventional drugs and adjuvant therapies can only relieve clinical symptoms to a certain extent, but cannot fundamentally delay the progress of the disease. With the rapid development of stem cells and reprogramming technologies around the world, cell transplantation to deal with neurodegenerative diseases including Parkinson's disease has become a new and potential therapy. This paper mainly summarizes the molecular mechanisms of Parkinson's disease, the preparation of autogenous dopaminergic neurons and the research progresses of dopaminergic neurons transplantation in the treatment of Parkinson's disease.
