Research progress in metabotropic glutamate receptor 5 and related nervous system diseases
10.3867/j.issn.1000-3002.2019.02.007
- Author:
Xiao-Dan CHEN
1
Author Information
1. Institute of Life Sciences, Jiangsu University
- Publication Type:Journal Article
- Keywords:
Metabotropic glutamate receptor 5;
Nervous system;
Signal transduction
- From:
Chinese Journal of Pharmacology and Toxicology
2019;33(2):130-137
- CountryChina
- Language:Chinese
-
Abstract:
The metabotropic glutamate receptor 5 (mGluR5), one of the most important mGluRs, exerts a biological effect through the second messenger. mGluR5 is mainly distributed in the cerebral cortex, hippocampus, and striatum in the form of dimers. It participates in neuronal excitability network regulation, neurogenesis, and synaptic plasticity associated with learning and memory by activating signaling pathways such as protein kinase C-inositol 1, 4, 5-triphosphate-diacylglycerol-Ca2+ and phosphatidylinositol 3-kinase-mammalian target of Rapamycin. Recently, mGluR5 has been confirmed to play an important role in diseases of the nervous system. Studies have shown that over-activation or inhibition of mGluR5 is closely related to the pathological processes of a variety of neurological diseases. A variety of drugs that selectively activate or inhibit mGluR5 activity have been used in the treatment of neurological diseases.
