Research advances in mechanism of doxorubicin-induced skeletal muscle dysfunction
10.3867/j.issn.1000-3002.2019.04.011
- Author:
Ai LI
1
Author Information
1. Department of Rehabilitation, Childern's Hospital of Shanghai Jiao Tong University, Shanghai Children's Hospital
- Publication Type:Journal Article
- Keywords:
Autophagy;
Doxorubicin;
Mitochondrial;
Oxidative stress;
Skeletal muscle dysfunction
- From:
Chinese Journal of Pharmacology and Toxicology
2019;33(4):314-320
- CountryChina
- Language:Chinese
-
Abstract:
Doxorubicin(DOX) is a widely used clinical anti-tumor drug for cancer. Unfortunately, DOX can also cause skeletal muscle dysfunction in a dose-dependent manner, leading to a significant decline in the quality of life of cancer patients. In this paper, we summarize the toxic effects of DOX, the characteristics of DOX-induced skeletal muscle dysfunction and its related mechanisms. We focus on pathological mechanisms, including oxidative stress, Ca2+overload, mitochondrial energy metabolism disorder, autophagy and apoptosis, nitric oxide concentration and amino acid metabolism and myogenic regulatory factor expression. Research prospects are outlined. It is expected to provide a theoretical basis for the clinical study of DOX toxicity.
