Relative bioavailability of clavulanic acid/amoxicillin dispersive tablets in healthy volunteers
- Author:
Yan-Hua SONG
1
Author Information
1. Department of Pharmacology, School of Medicine, Zhejiang University
- Publication Type:Journal Article
- Keywords:
Amoxicillin;
Clavulanic acid;
HPLC;
Relative bioavailability
- From:
Chinese Pharmacological Bulletin
2002;18(3):337-341
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the relative bioavailability of clavulanic acid/amoxicillin dispersive tablets. METHODS: A single oral administration of 125 mg clavulanic acid and 500 mg amoxicillin of dispersive tablet and Anqi tablet to 18 healthy male volunteers in a randomized cross-over study. The plasma concentration of clavulanic acid and amoxicillin simultaneous were determined with HPLC. RESULTS: The pharmacokinetic parameters of dispersive tablet and Anqi tablet for clavulanic acid were: Tmax (0.89± 0.25) h and (1.01±0.30) h; Cmax (1.92±0.64) mg·L-1 and (1.49±0.65) mg·L-1; AUC0→∞ (4.347±1.542) mg·h·L-1 and (3.395±1.468) mg·h·L-1, the pharmacokinetic parameters for amoxycillin were: Tmax (1.15±0.41) h and (1.34±0.40) h; Cmax (5.81±1.40) mg·L-1 and (4.60±1.37) mg·L-1; AUC0→∞ (13.472±3.114) mg·h·L-1 and (11.937±2.735) mg·h·L-1. The clavulanic acid Tmax of clavulanic acid/amoxicillin dispersive tablet was significantly shorter, clavulanic acid and amoxicillin Cmax, AUC0→∞ of clavulanic acid/amoxicillin dispersive tablet were significantly greater than the control Anqi tablet respectively, while there was no significant difference between amoxicillin Tmax of two tablets. CONCLUSION: The bioavailability of clavulanic acid/amoxicillin dispersive tablet is superior to Anqi tablet.
