The glucose-lowering effect of stilbenoids E1 and mechanism
- Author:
Gui-Qing ZHAO
1
Author Information
1. Institute of Radiation Medicine, Acad. of Military Medical Sciences
- Publication Type:Journal Article
- Keywords:
Blood glucose;
NIDDM rats;
OGTT;
Stilbenoid E1
- From:
Chinese Pharmacological Bulletin
2002;18(3):320-322
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the glucose-lowering effect of orally administered stilbenoid E1 on rats with experimental non-insulin dependent diabetes mellitus(NIDDM). METHODS: The rat model of NIDDM was established by tail-vein injection of a low dose of freshly prepared streptozotocin (STZ, 0.1 mmol·kg-1 which can injure the islet cells and cause impairment of glucose tolerance. Then, NIDDM rats were fed with high glucose-high fat diets in order to make them obese. RESULTS: stilbenoid E1 could significantly lower the fasting blood glucose and blood glucose levels of 60 min and 120 min in oral glucose tolerance test (OGTT) in NIDDM rats. However, stilbenoid E1 (0.1 mmol·L-1 and 0.001 mmol·L-1) in buffer with or without glucose could not stimulate βTC-3 cells to secret insulin. CONCLUSION: stilbenoid E1 has a great glucose-lowering effect by means of improving the effectiveness of insulin, but not by stimulating the islet cells to secret insulin.
