Effects of ethanol on isolated guinea pig atria
- Author:
Hao HU
1
Author Information
1. Department of Pharmacology, School of Medicine, Xi 'an Jiaotong University
- Publication Type:Journal Article
- Keywords:
Contractility;
Ethanol;
Heart atria;
Post-rest potentiation
- From:
Chinese Pharmacological Bulletin
2002;18(3):278-280
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effects of ethanol on physiological characteristics of atria in isolated guinea pig. METHODS: The effects of ethanol on contractility, spontaneous beat of right atrium, function refractory, post-rest potentiation and positive staircase phenomenon were observed in isolated guinea pig left and right atria. RESULTS: Ethanol (12.5, 25.0, 50.0, 100.0, 200.0 mmol · L-1) prominently inhibited the contractive force and decreased spontaneous beat of right atrium. Ethanol (12.5, 25.0, 50.0, 100.0, 200.0 mmol · L-1) inhibited the contractive force of left atrium, and markedly decreased the post-rest potentiation of myocardial contractility in left atrium. Ethanol of high concentration (100 200 mmol · L-1) prolonged the function refractory period and depressed the positive staircase phenomenon of isolated guinea pig left atrium. CONCLUSION: The ethanol induces inhibitory effects of the spontaneous beat, contractility, post-rest potentiation, positive staircase phenomenon and prolonged the function refractory period. The mechanism by which ethanol induces the negative chronotropic and inotropic effects may be related to decreasing the amount of calcium released from intracellular stores.
