Effects of chloride channel blockers on KCl and 5-HT-induced contractile response at rabbit basilar artery rings
- Author:
Yan DING
1
Author Information
1. Dept. of Pharmacology, Sun Yet-sen Univ. of Medical Science
- Publication Type:Journal Article
- Keywords:
5-HT;
Basilar artery;
Ca2+ channels;
Chloride channel blockers;
KCl
- From:
Chinese Pharmacological Bulletin
2002;18(3):267-271
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effects of different kinds of chloride channel blockers on KCl and 5-HT-induced contractile responses in cerebrovascular smooth muscle. METHOD: The tension of rabbit basilar artery rings was measured. RESULTS: 1 DIDS, furosemide and NPPB inhibited the responses to KCl and 5-HT in a concentration- dependent manner. The effects of DIDS, furosemide and NPPB on the response to 5-HT were stronger than that to KCl. 2 When SK&F 96365 evoked a maximum inhibitory effect on 5-HT-induced response, subsequent additions of DIDS, furosemide and NPPB could further produced vascular relaxation. CONCLUSION: The chloride channel participates KCl and 5-HT-induced contractile responses in cerebral basilar artery.
