Pathological significance and mechanism of advanced glycation end-products
- Author:
Mian-En SUN
1
Author Information
1. Chinese Academy of Medical Science, Chinese Union Medical College
- Publication Type:Journal Article
- Keywords:
AGEs;
Aging;
Diabetes;
Maillard reaction
- From:
Chinese Pharmacological Bulletin
2002;18(3):246-249
- CountryChina
- Language:Chinese
-
Abstract:
Advanced Glycation End-products (AGEs) are the products of non-enzymatic glycation protein. It has been demonstrated that AGEs are closely correlated to a variety of diseases such as diabetes, vascular complications, aging and renal diseases, AGEs play important roles in the development of these diseases. They can effect the function of cells and tissues directly, and also mediate pathological reactions through binding with special receptors. The present paper reviews the procedures of AGEs production, action mechanism and pathology of AGEs.
