Effects of TFC on the right ventricle papillary muscles of guinea pig
- Author:
Sha-Sha ZHANG
1
Author Information
1. Dept. of Pharmacology, Inner Mongolia Medical College
- Publication Type:Journal Article
- Keywords:
Choeropondias axillaris;
Contractility;
Excitability;
Functional refractory period (FRP);
Guinea pig;
Papillary muscle;
Total flavones of choeropondias axillaris(TFC)
- From:
Chinese Pharmacological Bulletin
2002;18(2):226-229
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the mechanism of effects about total flavones of choeropondias axillaris (TFC) to heart. METHODS: The effects of TFC on contractility were investigated through acting on the guinea pig right ventricle papillary muscles. RESULTS: TFC decreased both the contractility and contraction rate of papillary muscles. The quantity-effect curve of CaCl2 was shifted to right after giving TFC. TFC 30.4 μmol·L-1 prolonged remarkably the functional refractory period (FRP) of guinea pig right ventricle papillary muscles, but exerted no effect on excitability. CONCLUSION: TFC can inhibit the Ca2+ influx into cell in a concentration-dependent manner.
