Protective effect of total salvianolic acid against cerebral ischemia-reperfusion injury
- Author:
De-Cheng REN
1
Author Information
1. Institute of Materia Medica, Peking Union Medical College, Chinese Academy of Medical Sciences
- Publication Type:Journal Article
- Keywords:
Antioxidant activity;
Ischemia-reperfusion;
Total salvianolic acid
- From:
Chinese Pharmacological Bulletin
2002;18(2):219-221
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the protective effect of total salvianolic acid against cerebral ischemia-reperfusion injury. METHODS: The cerebral ischemia-reperfusion model in mice was made by means of ligating bilateral common carotid arteries in mice. After reperfusion, latency, error number of step down test and the gasping time after cutting head in ischemia-reperfusion mice were recorded. Spectrophotometric assay were used to measure the activity of superoxide dismutase (SOD), the contents malondialdehyde (MDA) and glutathione peroxidase (GSH) in brain of experimental mice brain homogenate. RESULTS: In step-down test, the ischemia-reperfusion impaired the function of learning and memory in mice. The total salvianolic acid markedly improved the function of learning and memory, reduced the error number and extended the latency in ischemia reperfusion mice. The total salvianolic acid also significantly inhibited the changes of SOD, MDA and GSH in the cerebrum induced by ischemia-reperfusion. CONCLUSION: The total salvianolic acid has protective effect against cerebral ischemia-reperfusion injury via its antioxidant activity.
